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Diabetes Control Matters

A Closer Look At Oral Agents

Today, there are several kinds of oral agents, or diabetes pills, available for the treatment of type 2 diabetes. If you have type 2 diabetes, your doctor and health care team can help you decide which oral agent or combination of oral agents are the best for you.

Here are some general tips about oral agents:

  • Diabetes pills are not insulin
  • Many doctors combine one oral agent with another or with insulin
  • Exercise and weight loss improve how well the diabetes pills work, which can sometimes help reduce the amount of diabetes medicine you have to take.
  • Taking insulin does not mean your diabetes is "worse" than the diabetes of a person who takes pills. It means that it is right for you at this time.
Brand Name Generic Name How They Work Possible Side Effects
Diabinese
Dymelor
Orinase
Tolinase
Diabeta/Micronase
Glynase
Glucotrol
Glucotrol XL
Amaryl
Chlorpropamide
Acetohexamide
Tolbutamide
Tolazamide
Glyburide
Glyburide
Glipizide
Glipizide
Glimepiride
Helps the pancreas release insulin • Low blood sugar
• Skin rash
• Weight Gain
Glucopahge Metformin Keeps the liver from making too much sugar • Upset stomach, take with food to avoid
• Diarrhea
• Gas & Bloating
• Avoid if you have kidney problems
Avandia
Actos
Troglitazone
Rosiglitazone
Pioglitazone
Helps the body use insulin better • Take with food for best results
• Avoid if you have kidney or liver problems
• Requires frequent liver function tests
• Weight Gain
Precose
Glyset
Acarbose
Miglitol
Slows absorption of sugar from the intestines after a meal • Stomach discomfort
• Gas & diarrhea
• Increasing dose slowly helps tolerance
• If taken in combination with sulfonylureas, can make low blood sugar more difficult to treat
Prandin Repaglinide Helps the pancreas release insulin • Low blood sugar
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 Battle Creek Health System
 300 North Avenue
 Battle Creek, Michigan 49017
Phone:
1-269-966-8000